Prednisone and prednisolone are synthetic corticosteroids that mimic the actions of cortisol, a hormone naturally produced by the adrenal glands. The primary difference between the two lies in their metabolism in the liver. Prednisone is converted to prednisolone in the liver, which is the active form of the drug. As a result, prednisolone is considered more potent and has a higher bioavailability compared to prednisone.



